by According to a study, thousands of cancer cases could possibly be prevented if more women offer breast removal operation.
Some people who already have breasts are offered a mastectomy CancerHowever, studies indicate that around 6,500 cases could be prevented each year if more preventive interventions were carried out.
Risk-reducing mastectomies (RRM) are currently only one option for women with the BRCA1, BRCA2, Palb2 genes.
The study, however, states that people with other genes – including ATM, Thek2, Rad51c, Rad51d – could benefit if they also have other high -risk factors.
This includes the family history of the disease, whether they were breastfeeding, the mammogram density and the number of children they had.
The researchers suggest that if all women could be identified 30 to 55 with a risk of 35% or more – and they had all the RRM – estimated 6,538 cases could be prevented every year.
This corresponds to about 11% of the 59,000 British women who were diagnosed annually.
The economic assessment of Queen Mary University of London and the London School of Hygiene and Tropical Medicine (LSHTM) said that this would be an inexpensive strategy.
It added that women who wear one of the other genes associated with breast cancer could possibly be found by “cascades tests” where family members are offered tests.
One of the authors said that a risk factor for offering RRM was defined for the first time.
“Our results could have significant clinical effects to expand access to mastectomy about those patients with well -known genetic susceptibility to high penetrance genes – BRCA1/ BRCA2/ PALB2 – which is traditionally offered,” said Professor Ranjit, Professor of Gynecological Oncology at Queen Mary.
“We recommend that more research is carried out to evaluate the acceptance, recording and long -term results of RRM in this group,” he added.
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Louise Grimsdell, breast cancer now Senior Clinical Nurse Specialist, emphasized that women should consider all options – not just an operation.
“While this modeling provides valuable insights into the cost efficiency of risk -reducing mastectomy for women with a high risk of developing breast cancer, all of the risk management options suitable for them must be offered,” she said.
“The choice of a risk -reducing operation is a complex and deeply personal decision associated with emotional and physical effects,” added Ms. Grimsdell.
“So they are important women who can take all their options into account, including screening and risk discovery medication, and are supported by their clinician to make a well-founded decision that is suitable for them.
“It is also crucial that the unacceptable long wait that far too many women who have chosen risk -determining operations are urgently tackled.”
The study appears in the Jama Oncology magazine.
