by Since the US regulatory authorities restrict COVID-MRNA vaccines and examine the shots again as an independent vaccine consultant, the scientists fear that an unlikely goal could be next: Cancer research.
Messenger -RNA or mRNA, vaccines, have shown themselves to treat and prevent cancer that were often difficult to treat, such as pancreatic cancer, brain tumors and others.
However, the groundbreaking research could decrease if federal and state officials aim on MRNA recordings, including the termination of federal financing for bird flu -mrNA vaccines, the restriction of existing mRNA vaccines and in some places that propose laws against the vaccines.
The Trump government has also implemented unprecedented cuts for cancer research, including research cuts and widespread layoffs at the National Institutes of Health (NIH).
Related: Pregnant doctor denied COVID-19-vaccine suing the administration of Trump
According to the crowdsourced Project Grant Watch, at least 16 grants were ended or frozen with the word “MRNA”, and scientists were asked to remove mrNA vaccines from their research applications, KFF Health News reported in March.
The researchers fear that therapeutic cancer vaccines against mRNA vaccines will be “integrated into this tidal shaft,” said Aaron Sasson, head of surgical oncology at Stony Brook University, in April.
According to Elias Sayour, professor of pediatric oncology research at the University of Florida, “the next few years are the most critical,” said Elias Sayour.
“If the previous progress that we have made so far – which was amazing – if this is only stopped or hindered, this can absolutely influence the trajectory and the bow,” he said.
The uncertainty about mRNA and research on the whole could also discourage new projects from the start, he said.
“If we continue to grasp these profits in the next 10 or 20 years, I see a scenario in which we have completely changed the way we take care of a large part of human diseases,” he said.
Studies on MRNA cancer vaccines have been underway for more than a decade, with more than 120 clinical studies to treat and prevent cancer. MRNA recordings have promised to prevent the return of head and neck cancer; Lymphoma; Breast cancer, in which 11.6% of all cancer deaths in the United States make up; Colon cancer; Lung cancer; And kidney cancer, among other things.
Pancreatic cancer has a survival rate of 10% and is the second most common cause of death for cancer in the United States. In a small study, however, about half of the patients who received an MRNA vaccine saw their cancer back, and they still had strong immune responses three years later.
Early MRNA vaccine attempts also showed that the recurrence of the melanoma could be cut in half. And a small study that was also made by Sayour on the Glioblastom showed that the vaccines influenced the tumors within 48 hours.
As with any vaccine, mRNA -cancer vaccines train the body to recognize and destroy harmful cells.
In contrast to foreign pathogens such as infectious diseases, cancer is caused by the growth of the patient’s own cells.
Some cancer vaccines are very personalized and use a patient’s own cancer cells to treat their tumors or train their immune system to kill these dangerous cells when they come back.
“The ability to create specific vaccines for patients has an enormous, enormous promise, but that was the technology that was not possible five or ten years ago,” said Sasson. “It is really a shift in paradigm how we treat cancer.”
The researchers also investigate vaccines that cancer cells target by identifying “fingerprints” of certain cancer, said Sayour.
In addition, vaccines for other diseases such as type -1 diabetes and multiple sclerosis could be created, he said.
“It has the potential to eliminate a large part of the chronic morbidity that we see from diseases, to heal, to heal diseases that are degenerative to overcome cancer development and heal patients,” said Sayour. “MRNA could be health care that was the movable printing machine for human knowledge.”
The decision-makers of the federal government and the state have targeted MRNA vaccines in recent months.
Vinay Prasad, director of the Center for Biological Assessment and Research at the US Food and Drug Administration (FDA), reports on the agency scientist about the restriction of some COVID vaccines, including a new MRNA shot from Moderna, for children who are older than 12 older. Prasad also introduced similar restrictions on the Novavax Covid shot, which does not use a mRNA.
On Thursday, the FDA approved the original COVID -MRNA vaccine from Moderna for children between the ages of six months and 11 years -but they have limited their use to children with at least one underlying illness. (The vaccine for people who are older than 12 years old was approved in 2022.)
Prasad argued in two memos recently published by the FDA that the risks of Covid had dropped, while “known and unknown” side effects could outweigh the advantages of vaccination.
Covid remains a main cause of death in the United States with 178 deaths in the week on June 7, the last week, for which the US centers offer complete data for the control and prevention of diseases (CDC).
At the meeting of the consulting committee for immunization practices (ACIP) of the CDC in June, two of the new vaccination consultants, which were appointed by the secretary of the Health and Human Services (HHS), Robert F. Kennedy JR, after releasing the previous 17 consultants -formed the security of the Koven -MRNA vaccines that have been shot showed.
Vicky Piscorth, a registered nurse who voluntarily reported to the National Vaccine Information Center for years, said that she was “very concerned” about side effects of the COVID MRNA recordings and asked for more security data, including “reproductive oxicity”.
Shortly before he was appointed in the Acip, PiscoW and the founder of the national vaccine information center argued that the FDA should not recommend MRNA COVID-19 recordings for anyone, “until adequate scientific evidence for both healthy and those who are older or chronically ill, prove security and effectiveness.
At the June ACIP meeting of Retsef Levi, professor of operational management at the with Sloan School of Management, he believed that MRNA side effects were “reported with installments, the other vaccines far exceed, even if they normalize something that suggests something, I think”.
Previously, Levi argued: “The evidence is increasingly and undeniable that mRNA vaccines, especially in young people, do serious damage. We don’t have to stop giving them immediately!”
Another new ACIP consultant, Robert Malone, has repeatedly argued against mRNA vaccines.
In 2021, Kennedy, the then chairman of the anti-Accacine organization Children’s Health Defense, applied for all the permits and future permits of all covid vaccines. He has ever called Covid Shots the “deadliest vaccine”.
In May, Kennedy changed the recommendations of the Covid vaccine from “should” to “Mai” for children and completely eliminated the recommendation for pregnant women.
Also in May, the United States terminated contracts of $ 766 million for researching mRNA vaccines against H5N1 bird flu. The investment in the mRNA vaccine was neither “scientifically nor ethically justified,” said Andrew Nixon, the HHS communication director, in statements to the media and added that “mRNA technology remains tested”.
Millions of mRNA vaccines were administered worldwide, and vaccines have proven to be safe and effective in several studies.
Bans or restrictions on mRNA vaccinations were introduced in seven countries. Such a legislative template in Idaho tried to pause “gene therapy vaccinations” for 10 years -a category in which they could incorrectly place covid vaccines and influence other therapeutic agents.
Similarly, in the state of Washington in Franklin County, a resolution adopted a resolution in which the local health facility was asked to stop and promote the vaccines of gene therapy. You also incorrectly included Covid -MRNA recordings in this category.
“There is now this burned Earth mentality, but I hope that, as soon as the dust has taken off, we restore or allow vaccine work so that we can continue to continue cancer,” said Sasson.
Cancer is the second most common cause of death in the United States, and two out of five people are diagnosed in any form of cancer in their lives.
There are currently only two vaccines approved by the FDA that prevent cancer from hepatitis B and human papillomavirus (HPV)-and both were attacked by anti-vaccine activists.
In January, Trump organized Stargate Ai in the White House. The project could finally identify cancer and develop MRNA vaccines in days, said Larry Ellison, chairman of the Tech company Oracle, who is involved in the project.
The project is financed by private, non -federal, dollars, but work on cancer would be based, among other things, on researching cancer and mRNA.
However, the Trump government has reduced other critical means of cancer research, prevention and treatment.
In the first three months of its term through the National Cancer Institute (NCI), the administration canceled more than $ 180 million and suggested to shorten $ 2.7 billion from the Cancer Center in the next NIH budget.
The administration has reduced financing for some family planning providers who often offer demonstrations for HPV and other cancer markers.
The legislator has also carried out enormous cuts in Medicaid and insurance through the Affordable Care Act (ACA), which could mean that insured and under -insured people are not waiting for cancer treatment longer.
“There is the potential for great damage that massive problems with public health during this really broad approach to cancel research will be put aside,” said Sasson. “There is considerable damage that is done by these comprehensive changes.”
For scientists who still have funds or those who enter the field, “there are enormous uncertainties about what the future will look like,” said Sasson.
However, he is optimistic that MRNA vaccines against cancer and other diseases will be able to get ahead.
Scientists are often “just trying to survive financing cuts”, but that is not entirely correct.
Sayour repeated concerns about indirect and direct forces that shape the progress on MRNA vaccines.
“But I also want to be optimistic that our best days are ahead of us,” he said.
